MYC Overexpression Induces Prostatic Intraepithelial Neoplasia and Loss of Nkx3.1 in Mouse Luminal Epithelial Cells

Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate[1]. However, prior studies have not determined precisely when, and in which cell types, MYC is induced. Using immunohistochemistry (IHC) to lo...

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Autores principales: Iwata, Tsuyoshi, Schultz, Denise, Hicks, Jessica, Hubbard, Gretchen K., Mutton, Laura N., Lotan, Tamara L., Bethel, Carlise, Lotz, Matthew T., Yegnasubramanian, Srinivasan, Nelson, William G., Dang, Chi V., Xu, MengMeng, Anele, Uzoma, Koh, Cheryl M., Bieberich, Charles J., De Marzo, Angelo M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828486/
https://ncbi.nlm.nih.gov/pubmed/20195545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009427
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