MYC Overexpression Induces Prostatic Intraepithelial Neoplasia and Loss of Nkx3.1 in Mouse Luminal Epithelial Cells

Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate[1]. However, prior studies have not determined precisely when, and in which cell types, MYC is induced. Using immunohistochemistry (IHC) to lo...

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Detalhes bibliográficos
Main Authors: Iwata, Tsuyoshi, Schultz, Denise, Hicks, Jessica, Hubbard, Gretchen K., Mutton, Laura N., Lotan, Tamara L., Bethel, Carlise, Lotz, Matthew T., Yegnasubramanian, Srinivasan, Nelson, William G., Dang, Chi V., Xu, MengMeng, Anele, Uzoma, Koh, Cheryl M., Bieberich, Charles J., De Marzo, Angelo M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828486/
https://ncbi.nlm.nih.gov/pubmed/20195545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009427
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