Myc Enforces Overexpression of EZH2 in Early Prostatic Neoplasia via Transcriptional and Post-transcriptional Mechanisms

EZH2 is part of the PRC2 polycomb repressive complex that is overexpressed in multiple cancer types and has been implicated in prostate cancer initiation and progression. Here, we identify EZH2 as a target of the MYC oncogene in prostate cancer and show that MYC coordinately regulates EZH2 through t...

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Bibliographic Details
Main Authors: Koh, Cheryl M., Iwata, Tsuyoshi, Zheng, Qizhi, Bethel, Carlise, Yegnasubramanian, Srinivasan, De Marzo, Angelo M.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2011
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248223/
https://ncbi.nlm.nih.gov/pubmed/21941025
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