MYC Overexpression Induces Prostatic Intraepithelial Neoplasia and Loss of Nkx3.1 in Mouse Luminal Epithelial Cells

Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate[1]. However, prior studies have not determined precisely when, and in which cell types, MYC is induced. Using immunohistochemistry (IHC) to lo...

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Main Authors: Iwata, Tsuyoshi, Schultz, Denise, Hicks, Jessica, Hubbard, Gretchen K., Mutton, Laura N., Lotan, Tamara L., Bethel, Carlise, Lotz, Matthew T., Yegnasubramanian, Srinivasan, Nelson, William G., Dang, Chi V., Xu, MengMeng, Anele, Uzoma, Koh, Cheryl M., Bieberich, Charles J., De Marzo, Angelo M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828486/
https://ncbi.nlm.nih.gov/pubmed/20195545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009427
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