MYC Overexpression Induces Prostatic Intraepithelial Neoplasia and Loss of Nkx3.1 in Mouse Luminal Epithelial Cells

Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate[1]. However, prior studies have not determined precisely when, and in which cell types, MYC is induced. Using immunohistochemistry (IHC) to lo...

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Bibliografiset tiedot
Päätekijät: Iwata, Tsuyoshi, Schultz, Denise, Hicks, Jessica, Hubbard, Gretchen K., Mutton, Laura N., Lotan, Tamara L., Bethel, Carlise, Lotz, Matthew T., Yegnasubramanian, Srinivasan, Nelson, William G., Dang, Chi V., Xu, MengMeng, Anele, Uzoma, Koh, Cheryl M., Bieberich, Charles J., De Marzo, Angelo M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2010
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828486/
https://ncbi.nlm.nih.gov/pubmed/20195545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009427
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