Global Levels of H3K27me3 Track with Differentiation in Vivo and Are Deregulated by MYC in Prostate Cancer

Cancer cells and stem cells share a number of biological characteristics including abundant amounts of decondensed chromatin. However, the molecular correlates and the factors involved in altering chromatin structure in cancer cells are not well known. Here, we report that less differentiated stem-l...

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Bibliographische Detailangaben
Hauptverfasser: Pellakuru, Laxmi G., Iwata, Tsuyoshi, Gurel, Bora, Schultz, Denise, Hicks, Jessica, Bethel, Carlise, Yegnasubramanian, Srinivasan, De Marzo, Angelo M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2012
Schlagworte:
Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409442/
https://ncbi.nlm.nih.gov/pubmed/22713676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.04.021
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