Global Levels of H3K27me3 Track with Differentiation in Vivo and Are Deregulated by MYC in Prostate Cancer

Cancer cells and stem cells share a number of biological characteristics including abundant amounts of decondensed chromatin. However, the molecular correlates and the factors involved in altering chromatin structure in cancer cells are not well known. Here, we report that less differentiated stem-l...

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Detalhes bibliográficos
Main Authors: Pellakuru, Laxmi G., Iwata, Tsuyoshi, Gurel, Bora, Schultz, Denise, Hicks, Jessica, Bethel, Carlise, Yegnasubramanian, Srinivasan, De Marzo, Angelo M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2012
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409442/
https://ncbi.nlm.nih.gov/pubmed/22713676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.04.021
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