A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

Irreversible cell growth arrest, a process termed cellular senescence, is emerging as an intrinsic tumor suppressive mechanism. Oncogene-induced senescence is thought to be invariably preceded by hyperproliferation, aberrant replication, and activation of a DNA damage checkpoint response (DDR), rend...

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Main Authors: Alimonti, Andrea, Nardella, Caterina, Chen, Zhenbang, Clohessy, John G., Carracedo, Arkaitz, Trotman, Lloyd C., Cheng, Ke, Varmeh, Shohreh, Kozma, Sara C., Thomas, George, Rosivatz, Erika, Woscholski, Rudiger, Cognetti, Francesco, Scher, Howard I., Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827955/
https://ncbi.nlm.nih.gov/pubmed/20197621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40535
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