CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis

Ewing sarcoma (EWS) is an aggressive bone tumor of uncertain cellular origin. CD99 is a membrane protein that is expressed in most cases of EWS, although its function in the disease is unknown. Here we have shown that endogenous CD99 expression modulates EWS tumor differentiation and malignancy. We...

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Autori principali: Rocchi, Anna, Manara, Maria Cristina, Sciandra, Marika, Zambelli, Diana, Nardi, Filippo, Nicoletti, Giordano, Garofalo, Cecilia, Meschini, Stefania, Astolfi, Annalisa, Colombo, Mario P., Lessnick, Stephen L., Picci, Piero, Scotlandi, Katia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827943/
https://ncbi.nlm.nih.gov/pubmed/20197622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36667
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