CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis

Ewing sarcoma (EWS) is an aggressive bone tumor of uncertain cellular origin. CD99 is a membrane protein that is expressed in most cases of EWS, although its function in the disease is unknown. Here we have shown that endogenous CD99 expression modulates EWS tumor differentiation and malignancy. We...

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Detalhes bibliográficos
Main Authors: Rocchi, Anna, Manara, Maria Cristina, Sciandra, Marika, Zambelli, Diana, Nardi, Filippo, Nicoletti, Giordano, Garofalo, Cecilia, Meschini, Stefania, Astolfi, Annalisa, Colombo, Mario P., Lessnick, Stephen L., Picci, Piero, Scotlandi, Katia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827943/
https://ncbi.nlm.nih.gov/pubmed/20197622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36667
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