Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85α, p55α, and p50α

The phosphoinositide 3-kinase (PI3K) family has multiple vascular functions, but the specific regulatory isoform supporting lymphangiogenesis remains unidentified. Here we report that deletion of the Pik3r1 gene, encoding the regulatory subunits p85α, p55α, and p50α impairs lymphatic sprouting and m...

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Hauptverfasser: Mouta-Bellum, Carla, Kirov, Aleksander, Miceli-Libby, Laura, Mancini, Maria L., Petrova, Tatiana V., Liaw, Lucy, Prudovsky, Igor, Thorpe, Philip E., Miura, Naoyuki, Cantley, Lewis C., Alitalo, Kari, Fruman, David A., Vary, Calvin P.H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826787/
https://ncbi.nlm.nih.gov/pubmed/19705443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.22078
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