Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85α, p55α, and p50α

The phosphoinositide 3-kinase (PI3K) family has multiple vascular functions, but the specific regulatory isoform supporting lymphangiogenesis remains unidentified. Here we report that deletion of the Pik3r1 gene, encoding the regulatory subunits p85α, p55α, and p50α impairs lymphatic sprouting and m...

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Detalhes bibliográficos
Main Authors: Mouta-Bellum, Carla, Kirov, Aleksander, Miceli-Libby, Laura, Mancini, Maria L., Petrova, Tatiana V., Liaw, Lucy, Prudovsky, Igor, Thorpe, Philip E., Miura, Naoyuki, Cantley, Lewis C., Alitalo, Kari, Fruman, David A., Vary, Calvin P.H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826787/
https://ncbi.nlm.nih.gov/pubmed/19705443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.22078
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