Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85α, p55α, and p50α

The phosphoinositide 3-kinase (PI3K) family has multiple vascular functions, but the specific regulatory isoform supporting lymphangiogenesis remains unidentified. Here we report that deletion of the Pik3r1 gene, encoding the regulatory subunits p85α, p55α, and p50α impairs lymphatic sprouting and m...

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Bibliografiske detaljer
Main Authors:	Mouta-Bellum, Carla, Kirov, Aleksander, Miceli-Libby, Laura, Mancini, Maria L., Petrova, Tatiana V., Liaw, Lucy, Prudovsky, Igor, Thorpe, Philip E., Miura, Naoyuki, Cantley, Lewis C., Alitalo, Kari, Fruman, David A., Vary, Calvin P.H.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2009
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2826787/ https://ncbi.nlm.nih.gov/pubmed/19705443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.22078
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Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85α, p55α, and p50α

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