Heme-Coordinating Inhibitors of Neuronal Nitric Oxide Synthase. Iron-Thioether Coordination is Stabilized by Hydrophobic Contacts Without Increased Inhibitor Potency

The heme-thioether ligand interaction often occurs between heme iron and native methionine ligands, but thioether-based heme-coordinating (type II) inhibitors are uncommon due to the difficulty in stabilizing the Fe-S bond. Here, a thioether-based inhibitor (3) of neuronal nitric oxide synthase (nNO...

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Main Authors: Martell, Jeffrey D., Li, Huiying, Doukov, Tzanko, Martásek, Pavel, Roman, Linda J., Soltis, Michael, Poulos, Thomas L., Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826131/
https://ncbi.nlm.nih.gov/pubmed/20014790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja908544f
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