Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice

The lysosomal cysteine proteases cathepsin B (Ctsb) and cathepsin Z (Ctsz, also called cathepsin X/P) have been implicated in cancer pathogenesis. Compensation of Ctsb by Ctsz in Ctsb (−/−) mice has been suggested. To further define the functional interplay of these proteases in the context of cance...

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Detalhes bibliográficos
Main Authors: Sevenich, Lisa, Schurigt, Uta, Sachse, Kathrin, Gajda, Mieczyslaw, Werner, Fee, Müller, Sebastian, Vasiljeva, Olga, Schwinde, Anne, Klemm, Nicole, Deussing, Jan, Peters, Christoph, Reinheckel, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823914/
https://ncbi.nlm.nih.gov/pubmed/20133781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907240107
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