Gene Targeting of the Cysteine Peptidase Cathepsin H Impairs Lung Surfactant in Mice

BACKGROUND: The 11 human cysteine cathepsins are proteases mainly located in the endolysosomal compartment of all cells and within the exocytosis pathways of some secretory cell types. Cathepsin H (Ctsh) has amino- and endopeptidase activities. In vitro studies have demonstrated Ctsh involvement in...

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Hlavní autoři: Bühling, Frank, Kouadio, Martin, Chwieralski, Caroline E., Kern, Ursula, Hohlfeld, Jens M., Klemm, Nicole, Friedrichs, Nicole, Roth, Wera, Deussing, Jan M., Peters, Christoph, Reinheckel, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192174/
https://ncbi.nlm.nih.gov/pubmed/22022579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026247
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