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Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target

Lysosomal cysteine cathepsins belong to a family of 11 human proteolytic enzymes. Some of them correlate with progression in a variety of cancers and therefore are considered as potential therapeutic targets. Until recently, the contribution of individual cathepsins to tumorigenesis and tumor progre...

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Detalhes bibliográficos
Main Authors: Reinheckel, Thomas, Peters, Christoph, Krüger, Achim, Turk, Boris, Vasiljeva, Olga
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394080/
https://ncbi.nlm.nih.gov/pubmed/22798952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00133
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