Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix

During the process of tumor progression, cancer cells can produce the requisite growth- and invasion-promoting factors and can also rely on noncancerous cells in the tumor microenvironment as an alternative, cell-extrinsic source. However, whether the cellular source influences the function of such...

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Hauptverfasser: Akkari, Leila, Gocheva, Vasilena, Kester, Jemila C., Hunter, Karen E., Quick, Marsha L., Sevenich, Lisa, Wang, Hao-Wei, Peters, Christoph, Tang, Laura H., Klimstra, David S., Reinheckel, Thomas, Joyce, Johanna A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180975/
https://ncbi.nlm.nih.gov/pubmed/25274726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.249599.114
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