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Phospholipase Cγ1 is essential for T cell development, activation, and tolerance
Phospholipase Cγ1 (PLCγ1) is an important signaling effector of T cell receptor (TCR). To investigate the role of PLCγ1 in T cell biology, we generated and examined mice with T cell–specific deletion of PLCγ1. We demonstrate that PLCγ1 deficiency affects positive and negative selection, significantl...
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Hlavní autoři: | , , , , , , , , , , , , , |
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Médium: | Artigo |
Jazyk: | Inglês |
Vydáno: |
The Rockefeller University Press
2010
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Témata: | |
On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822604/ https://ncbi.nlm.nih.gov/pubmed/20123962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090880 |
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