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Modulation of the cold-activated cation channel TRPM8 by surface charge screening
TRPM8, a cation channel activated by cold and by cooling agents such as menthol and icilin, is critically involved in somatosensory cold sensation. Ion fluxes through TRPM8 are highly sensitive to changes in extracellular Ca(2+) and pH, but the mechanisms underlying this type of modulation are poorl...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Blackwell Science Inc
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2821726/ https://ncbi.nlm.nih.gov/pubmed/19948654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.183582 |
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