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Definition of two agonist types at the mammalian cold-activated channel TRPM8
Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channel gating are poorly understood. Here we show that AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the mammali...
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| 發表在: | eLife |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4985286/ https://ncbi.nlm.nih.gov/pubmed/27449282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17240 |
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