Definition of two agonist types at the mammalian cold-activated channel TRPM8

Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channel gating are poorly understood. Here we show that AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the mammali...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Janssens, Annelies, Gees, Maarten, Toth, Balazs Istvan, Ghosh, Debapriya, Mulier, Marie, Vennekens, Rudi, Vriens, Joris, Talavera, Karel, Voets, Thomas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2016
Pynciau:
Biophysics and Structural Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985286/
https://ncbi.nlm.nih.gov/pubmed/27449282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17240
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