Definition of two agonist types at the mammalian cold-activated channel TRPM8

Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channel gating are poorly understood. Here we show that AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the mammali...

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Detalhes bibliográficos
Publicado no:eLife
Principais autores: Janssens, Annelies, Gees, Maarten, Toth, Balazs Istvan, Ghosh, Debapriya, Mulier, Marie, Vennekens, Rudi, Vriens, Joris, Talavera, Karel, Voets, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985286/
https://ncbi.nlm.nih.gov/pubmed/27449282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17240
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