Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing

The complex repertoire of immune receptors generated by B and T cells enables recognition of diverse threats to the host organism. In this work, we show that massively parallel DNA sequencing of rearranged immune receptor loci can provide direct detection and tracking of immune diversity and expande...

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Detalhes bibliográficos
Main Authors: Boyd, Scott D., Marshall, Eleanor L., Merker, Jason D., Maniar, Jay M., Zhang, Lyndon N., Sahaf, Bita, Jones, Carol D., Simen, Birgitte B., Hanczaruk, Bozena, Nguyen, Khoa D., Nadeau, Kari C., Egholm, Michael, Miklos, David B., Zehnder, James L., Fire, Andrew Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819115/
https://ncbi.nlm.nih.gov/pubmed/20161664
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