Individual Variation in the Germline Ig Gene Repertoire Inferred from Variable Region Gene Rearrangements

Individual variation in the Ig germline gene repertoire leads to individual differences in the combinatorial diversity of the Ab repertoire, but the study of such variation has been problematic. The application of high-throughput DNA sequencing to the study of rearranged Ig genes now makes this poss...

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Publicado no:J Immunol
Main Authors: Boyd, Scott D., Gaëta, Bruno A., Jackson, Katherine J., Fire, Andrew Z., Marshall, Eleanor L., Merker, Jason D., Maniar, Jay M., Zhang, Lyndon N., Sahaf, Bita, Jones, Carol D., Simen, Birgitte B., Hanczaruk, Bozena, Nguyen, Khoa D., Nadeau, Kari C., Egholm, Michael, Miklos, David B., Zehnder, James L., Collins, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281569/
https://ncbi.nlm.nih.gov/pubmed/20495067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000445
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