Individual Variation in the Germline Ig Gene Repertoire Inferred from Variable Region Gene Rearrangements

Individual variation in the Ig germline gene repertoire leads to individual differences in the combinatorial diversity of the Ab repertoire, but the study of such variation has been problematic. The application of high-throughput DNA sequencing to the study of rearranged Ig genes now makes this poss...

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Pubblicato in:J Immunol
Autori principali: Boyd, Scott D., Gaëta, Bruno A., Jackson, Katherine J., Fire, Andrew Z., Marshall, Eleanor L., Merker, Jason D., Maniar, Jay M., Zhang, Lyndon N., Sahaf, Bita, Jones, Carol D., Simen, Birgitte B., Hanczaruk, Bozena, Nguyen, Khoa D., Nadeau, Kari C., Egholm, Michael, Miklos, David B., Zehnder, James L., Collins, Andrew M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281569/
https://ncbi.nlm.nih.gov/pubmed/20495067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000445
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