NMR analysis of G-protein βγ subunit complexes reveals a dynamic Gα-Gβγ subunit interface and multiple protein recognition modes

G-protein βγ (Gβγ) subunits interact with a wide range of molecular partners including: Gα subunits, effectors, peptides, and small molecule inhibitors. The molecular mechanisms underlying the ability to accommodate this wide range of structurally distinct binding partners are not well understood. T...

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Bibliographic Details
Main Authors: Smrcka, Alan V., Kichik, Nessim, Tarragó, Teresa, Burroughs, Michael, Park, Min-Sun, Itoga, Nathan K., Stern, Harry A., Willardson, Barry M., Giralt, Ernest
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818914/
https://ncbi.nlm.nih.gov/pubmed/20018744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909503107
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