CRFR1 is expressed on pancreatic β cells, promotes β cell proliferation, and potentiates insulin secretion in a glucose-dependent manner

Corticotropin-releasing factor (CRF), originally characterized as the principal neuroregulator of the hypothalamus-pituitary-adrenal axis, has broad central and peripheral distribution and actions. We demonstrate the presence of CRF receptor type 1 (CRFR1) on primary β cells and show that activation...

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Autors principals: Huising, Mark O., van der Meulen, Talitha, Vaughan, Joan M., Matsumoto, Masahito, Donaldson, Cynthia J., Park, Hannah, Billestrup, Nils, Vale, Wylie W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818901/
https://ncbi.nlm.nih.gov/pubmed/20080775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913610107
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