COX-2 Dependent Prostacyclin Formation and Blood Pressure Homeostasis: Targeted Exchange of COX Isoforms in Mice

RATIONALE: Cyclooxygenase (COX)-derived prostanoids (PGs) are involved in blood pressure (BP) homeostasis. Both traditional(t) nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit COX-1 and COX-2 and NSAIDs designed to be selective for inhibition of COX-2 cause sodium retention and elevate BP....

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Bibliographic Details
Main Authors: Yu, Ying, Stubbe, Jane, Ibrahim, Salam, Song, Wen-liang, Symth, Emer M., Funk, Colin D., FitzGerald, Garret A.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818801/
https://ncbi.nlm.nih.gov/pubmed/19940265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.204529
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