Sex-dependent compensatory mechanisms preserve blood pressure homeostasis in prostacyclin receptor–deficient mice

Inhibitors of microsomal prostaglandin E synthase 1 (mPGES-1) are in the early phase of clinical development. Deletion of mPges-1 in mice confers analgesia, restrains atherogenesis, and fails to accelerate thrombogenesis, while suppressing prostaglandin E(2) (PGE(2)), but increasing the biosynthesis...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Tang, Soon Y., Meng, Hu, Anderson, Seán T., Sarantopoulou, Dimitra, Ghosh, Soumita, Lahens, Nicholas F., Theken, Katherine N., Ricciotti, Emanuela, Hennessy, Elizabeth J., Tu, Vincent, Bittinger, Kyle, Weiljie, Aalim M., Grant, Gregory R., FitzGerald, Garret A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279587/
https://ncbi.nlm.nih.gov/pubmed/34101620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136310
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