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Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis

Prostaglandin (PG) E(2) is formed from PGH(2) by a series of PGE synthase (PGES) enzymes. Microsomal PGES-1(−/−) (mPGES-1(−/−)) mice were crossed into low-density lipoprotein receptor knockout (LDLR(−/−)) mice to generate mPGES-1(−/−) LDLR(−/−)s. Urinary 11α-hydroxy-9, 15-dioxo-2,3,4,5-tetranor-pros...

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Detalhes bibliográficos
Main Authors: Wang, Miao, Zukas, Alicia M., Hui, Yiqun, Ricciotti, Emanuela, Puré, Ellen, FitzGerald, Garret A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566188/
https://ncbi.nlm.nih.gov/pubmed/16973753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606586103
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