Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice

Prostacyclin (PGI(2)) is a vasodilator and platelet inhibitor, properties consistent with cardioprotection. More than a decade ago, inhibition of cyclooxygenase-2 (COX-2) by the nonsteroidal anti-inflammatory drugs (NSAIDs) rofecoxib and celecoxib was found to reduce the amount of the major metaboli...

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Detalhes bibliográficos
Main Authors: Yu, Ying, Ricciotti, Emanuela, Scalia, Rosario, Tang, Soon Yew, Grant, Gregory, Yu, Zhou, Landesberg, Gavin, Crichton, Irene, Wu, Weichen, Puré, Ellen, Funk, Colin D., FitzGerald, Garret A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882087/
https://ncbi.nlm.nih.gov/pubmed/22553252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003787
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