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Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice

Suppression of cyclooxygenase 2 (COX-2)–derived prostacyclin (PGI(2)) is sufficient to explain most elements of the cardiovascular hazard from nonsteroidal antinflammatory drugs (NSAIDs). However, randomized trials are consistent with the emergence of cardiovascular risk during chronic dosing with N...

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Détails bibliographiques
Auteurs principaux: Yu, Zhou, Crichton, Irene, Tang, Soon Yew, Hui, Yiqun, Ricciotti, Emanuela, Levin, Mark D., Lawson, John A., Puré, Ellen, FitzGerald, Garret A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340044/
https://ncbi.nlm.nih.gov/pubmed/22493243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115313109
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