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Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice

Suppression of cyclooxygenase 2 (COX-2)–derived prostacyclin (PGI(2)) is sufficient to explain most elements of the cardiovascular hazard from nonsteroidal antinflammatory drugs (NSAIDs). However, randomized trials are consistent with the emergence of cardiovascular risk during chronic dosing with N...

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מידע ביבליוגרפי
Main Authors: Yu, Zhou, Crichton, Irene, Tang, Soon Yew, Hui, Yiqun, Ricciotti, Emanuela, Levin, Mark D., Lawson, John A., Puré, Ellen, FitzGerald, Garret A.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340044/
https://ncbi.nlm.nih.gov/pubmed/22493243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115313109
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