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Niacin and biosynthesis of PGD(2) by platelet COX-1 in mice and humans
The clinical use of niacin to treat dyslipidemic conditions is limited by noxious side effects, most commonly facial flushing. In mice, niacin-induced flushing results from COX-1–dependent formation of PGD(2) and PGE(2) followed by COX-2–dependent production of PGE(2). Consistent with this, niacin-i...
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Главные авторы: | , , , , , , , , , , , |
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Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
American Society for Clinical Investigation
2012
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3314457/ https://ncbi.nlm.nih.gov/pubmed/22406532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59262 |
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