Niacin and biosynthesis of PGD(2) by platelet COX-1 in mice and humans

The clinical use of niacin to treat dyslipidemic conditions is limited by noxious side effects, most commonly facial flushing. In mice, niacin-induced flushing results from COX-1–dependent formation of PGD(2) and PGE(2) followed by COX-2–dependent production of PGE(2). Consistent with this, niacin-i...

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Détails bibliographiques
Auteurs principaux: Song, Wen-Liang, Stubbe, Jane, Ricciotti, Emanuela, Alamuddin, Naji, Ibrahim, Salam, Crichton, Irene, Prempeh, Maxwell, Lawson, John A., Wilensky, Robert L., Rasmussen, Lars Melholt, Puré, Ellen, FitzGerald, Garret A.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314457/
https://ncbi.nlm.nih.gov/pubmed/22406532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59262
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