Llwytho...

A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II

Etoposide is a widely used anticancer drug that targets topoisomerase II, an essential nuclear enzyme. However, despite the fact that it has been in use and studied for more than 30 years the specific site on the enzyme to which it binds is unknown. In order to identify the etoposide binding site(s)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chee, Gaik-Lean, Yalowich, Jack C., Bodner, Andrew, Wu, Xing, Hasinoff, Brian B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818565/
https://ncbi.nlm.nih.gov/pubmed/20006518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.11.048
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