Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cells

BACKGROUND: Somatic mutation in the X-linked phosphatidylinositol glycan class A gene (PIG-A) causes glycosyl phosphatidylinositol anchor deficiency in human patients with paroxysmal nocturnal hemoglobinuria. DESIGN AND METHODS: We produced an animal model of paroxysmal nocturnal hemoglobinuria by c...

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Main Authors: Visconte, Valeria, Raghavachari, Nalini, Liu, Delong, Keyvanfar, Keyvan, Desierto, Marie J., Chen, Jichun, Young, Neal S.
Format: Artigo
Jezik:Inglês
Izdano: Ferrata Storti Foundation 2010
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817023/
https://ncbi.nlm.nih.gov/pubmed/19679885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.011650
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