PPARγ antagonist attenuates mouse immune-mediated bone marrow failure by inhibition of T cell function

Acquired aplastic anemia is an immune-mediated disease, in which T cells target hematopoietic cells; at presentation, the bone marrow is replaced by fat. It was reported that bone marrow adipocytes were negative regulators of hematopoietic microenvironment. To examine the role of adipocytes in bone...

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Bibliografiske detaljer
Udgivet i:Haematologica
Main Authors: Sato, Kazuya, Feng, Xingmin, Chen, Jichun, Li, Jungang, Muranski, Pawel, Desierto, Marie J., Keyvanfar, Keyvan, Malide, Daniela, Kajigaya, Sachiko, Young, Neal S.
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697892/
https://ncbi.nlm.nih.gov/pubmed/26589913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.121632
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