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IFN-γ-mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure

Interferon gamma (IFN-γ) has been reported to have both negative and positive activity on hematopoietic cells, adding complexity to the interpretation of its pleiotropic functions. We examined the effects of IFN-γ on murine hematopoietic stem cells (HSCs) and progenitors in vitro and in vivo by usin...

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Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Chen, Jichun, Feng, Xingmin, Desierto, Marie J., Keyvanfar, Keyvan, Young, Neal S.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671109/
https://ncbi.nlm.nih.gov/pubmed/26491068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-652453
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