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Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cells
BACKGROUND: Somatic mutation in the X-linked phosphatidylinositol glycan class A gene (PIG-A) causes glycosyl phosphatidylinositol anchor deficiency in human patients with paroxysmal nocturnal hemoglobinuria. DESIGN AND METHODS: We produced an animal model of paroxysmal nocturnal hemoglobinuria by c...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Ferrata Storti Foundation
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2817023/ https://ncbi.nlm.nih.gov/pubmed/19679885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.011650 |
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