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Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

Membrane-bound Ras is activated by translocation of the Son of Sevenless (SOS) protein to the plasma membrane. SOS is inactive unless Ras is bound to an allosteric site on SOS, and the Dbl homology (DH) and Pleckstrin homology (PH) domains of SOS (the DH-PH unit) block allosteric Ras binding. We sho...

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Библиографические подробности
Главные авторы: Gureasko, Jodi, Kuchment, Olga, Makino, Debora Lika, Sondermann, Holger, Bar-Sagi, Dafna, Kuriyan, John
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816639/
https://ncbi.nlm.nih.gov/pubmed/20133692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913915107
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