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Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless
Membrane-bound Ras is activated by translocation of the Son of Sevenless (SOS) protein to the plasma membrane. SOS is inactive unless Ras is bound to an allosteric site on SOS, and the Dbl homology (DH) and Pleckstrin homology (PH) domains of SOS (the DH-PH unit) block allosteric Ras binding. We sho...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2816639/ https://ncbi.nlm.nih.gov/pubmed/20133692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913915107 |
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