Tsc2-Rheb Signaling Regulates EphA-Mediated Axon Guidance

Tuberous sclerosis complex is a disease caused by mutations in the TSC1 or TSC2 genes, which encode a protein complex that inhibits mTOR kinase signaling by inactivating the Rheb GTPase. Activation of mTOR promotes the formation of benign tumors in various organs while the mechanisms underlying the...

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Hauptverfasser: Nie, Du-yu, Di Nardo, Alessia, Han, Juliette M., Baharanyi, Hasani, Kramvis, Ioannis, Huynh, ThanhThao, Dabora, Sandra, Codeluppi, Simone, Pandolfi, Pier Paolo, Pasquale, Elena B., Sahin, Mustafa
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812631/
https://ncbi.nlm.nih.gov/pubmed/20062052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2477
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