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Tsc2-Rheb Signaling Regulates EphA-Mediated Axon Guidance
Tuberous sclerosis complex is a disease caused by mutations in the TSC1 or TSC2 genes, which encode a protein complex that inhibits mTOR kinase signaling by inactivating the Rheb GTPase. Activation of mTOR promotes the formation of benign tumors in various organs while the mechanisms underlying the...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2812631/ https://ncbi.nlm.nih.gov/pubmed/20062052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2477 |
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