CYP2C9*1B Promoter Polymorphisms, in Linkage with CYP2C19*2, Affect Phenytoin Autoinduction of Clearance and Maintenance Dose

The commonly prescribed antiepileptic drug phenytoin has a narrow therapeutic range and wide interindividual variability in clearance explained in part by CYP2C9 and CYP2C19 coding variants. After finding a paradoxically low urinary phenytoin metabolite (S)/(R) ratio in subjects receiving phenytoin...

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Hauptverfasser: Chaudhry, Amarjit S., Urban, Thomas J., Lamba, Jatinder K., Birnbaum, Angela K., Remmel, Rory P., Subramanian, Murali, Strom, Stephen, You, Joyce H., Kasperaviciute, Dalia, Catarino, Claudia B., Radtke, Rodney A., Sisodiya, Sanjay M., Goldstein, David B., Schuetz, Erin G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2010
Schlagworte:
Metabolism, Transport, and Pharmacogenomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812115/
https://ncbi.nlm.nih.gov/pubmed/19855097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.161026
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