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Genetic Predictors of Interindividual Variability in Hepatic CYP3A4 Expression
Variability in hepatic CYP3A4 cannot be explained by common CYP3A4 coding variants. We previously identified polymorphisms in pregnane X receptor (PXR) and ATP-binding cassette subfamily B member 1 (ABCB1) associated with CYP3A4 mRNA levels in small cohorts of human livers. However, the relative con...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental
Therapeutics
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2835441/ https://ncbi.nlm.nih.gov/pubmed/19934400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.160804 |
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