Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism

The cytochrome P450 (P450) enzymes are the predominant enzyme system involved in human drug metabolism. Alterations in the expression and/or activity of these enzymes result in changes in pharmacokinetics (and consequently the pharmacodynamics) of drugs that are metabolized by this set of enzymes. A...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Tracy, Timothy S., Chaudhry, Amarjit S., Prasad, Bhagwat, Thummel, Kenneth E., Schuetz, Erin G., Zhong, Xiao-bo, Tien, Yun-Chen, Jeong, Hyunyoung, Pan, Xian, Shireman, Laura M., Tay-Sontheimer, Jessica, Lin, Yvonne S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Symposium Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767386/
https://ncbi.nlm.nih.gov/pubmed/26681736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.067900
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