CYP2C9*1B Promoter Polymorphisms, in Linkage with CYP2C19*2, Affect Phenytoin Autoinduction of Clearance and Maintenance Dose

The commonly prescribed antiepileptic drug phenytoin has a narrow therapeutic range and wide interindividual variability in clearance explained in part by CYP2C9 and CYP2C19 coding variants. After finding a paradoxically low urinary phenytoin metabolite (S)/(R) ratio in subjects receiving phenytoin...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Chaudhry, Amarjit S., Urban, Thomas J., Lamba, Jatinder K., Birnbaum, Angela K., Remmel, Rory P., Subramanian, Murali, Strom, Stephen, You, Joyce H., Kasperaviciute, Dalia, Catarino, Claudia B., Radtke, Rodney A., Sisodiya, Sanjay M., Goldstein, David B., Schuetz, Erin G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812115/
https://ncbi.nlm.nih.gov/pubmed/19855097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.161026
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados