The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles

CYP2C19 rs12769205 alters an intron 2 branch point adenine leading to an alternative mRNA in human liver with complete inclusion of intron 2 (exon 2B). rs12769205 changes the mRNA reading frame, introduces 87 amino acids, and leads to a premature stop codon. The 1000 Genomes project (http://browser....

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Publicado no:Drug Metab Dispos
Main Authors: Chaudhry, Amarjit S., Prasad, Bhagwat, Shirasaka, Yoshiyuki, Fohner, Alison, Finkelstein, David, Fan, Yiping, Wang, Shuoguo, Wu, Gang, Aklillu, Eleni, Sim, Sarah C., Thummel, Kenneth E., Schuetz, Erin G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518065/
https://ncbi.nlm.nih.gov/pubmed/26021325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.064428
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