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Protein Kinase C Theta (PKCθ) Regulates KIT Expression and Proliferation in Gastrointestinal Stromal Tumors
Oncogenic KIT or PDGFRA receptor tyrosine kinase mutations are compelling therapeutic targets in gastrointestinal stromal tumors (GISTs), and the KIT/PDGFRA kinase inhibitor, imatinib, is standard of care for patients with metastatic GIST. However, most of these patients eventually develop clinical...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2811224/ https://ncbi.nlm.nih.gov/pubmed/18521081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.177 |
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