KIT Extracellular and Kinase Domain Mutations in Gastrointestinal Stromal Tumors

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms arising in the gastrointestinal tract. GISTs express the KIT receptor tyrosine kinase, and many cases have activating mutations in the KIT juxtamembrane region. We now report an analysis of KIT cDNA and genomic sequenc...

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Detalhes bibliográficos
Main Authors: Lux, Marcia L., Rubin, Brian P., Biase, Tara L., Chen, Chang-Jie, Maclure, Timothy, Demetri, George, Xiao, Sheng, Singer, Samuel, Fletcher, Christopher D.M., Fletcher, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2000
Assuntos:
Short Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876850/
https://ncbi.nlm.nih.gov/pubmed/10702394
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