Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and are Targetable by BET Bromodomain Inhibition

Gastrointestinal stromal tumor (GIST) is a mesenchymal neoplasm characterized by activating mutations in the related receptor tyrosine kinases KIT and PDGFRA. GIST relies on expression of these unamplified receptor tyrosine kinase (RTK) genes through a large enhancer domain, resulting in high expres...

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Publié dans:Cancer Res
Auteurs principaux: Hemming, Matthew L., Lawlor, Matthew A., Andersen, Jessica L., Hagan, Timothy, Chipashvili, Otari, Scott, Thomas G., Raut, Chandrajit P., Sicinska, Ewa, Armstrong, Scott A., Demetri, George D., Bradner, James E.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397693/
https://ncbi.nlm.nih.gov/pubmed/30630822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1888
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