Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome

Activating mutations in the KIT or PDGFRA receptor tyrosine kinases are hallmarks of gastrointestinal stromal tumor (GIST). The biological underpinnings of recurrence following resection or disease progression beyond kinase mutation are poorly understood. Utilizing chromatin immunoprecipitation with...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hemming, Matthew L., Lawlor, Matthew A., Zeid, Rhamy, Lesluyes, Tom, Fletcher, Jonathan A., Raut, Chandrajit P., Sicinska, Ewa T., Chibon, Frédéric, Armstrong, Scott A., Demetri, George D., Bradner, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016782/
https://ncbi.nlm.nih.gov/pubmed/29866822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802079115
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